Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions
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چکیده
منابع مشابه
Synthetic Physical Interactions Map Kinetochore-Checkpoint Activation Regions
The spindle assembly checkpoint (SAC) is a key mechanism to regulate the timing of mitosis and ensure that chromosomes are correctly segregated to daughter cells. The recruitment of the Mad1 and Mad2 proteins to the kinetochore is normally necessary for SAC activation. This recruitment is coordinated by the SAC kinase Mps1, which phosphorylates residues at the kinetochore to facilitate binding ...
متن کاملMps1 Phosphorylation by MAP Kinase Is Required for Kinetochore Localization of Spindle-Checkpoint Proteins
The spindle checkpoint delays anaphase onset until all chromosomes have achieved bipolar attachment to the spindle microtubules. Unattached kinetochores activate the spindle checkpoint by recruiting several spindle-checkpoint proteins, including Mps1, Mad1, Mad2, Bub1, Bub3, and BubR1 (Mad3 in yeast). In vertebrate cells, active MAP kinase (MAPK) is also enriched at unattached kinetochores and ...
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The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when microtubule binding is incomplete. The SAC might also respond to tension; however, how cells can sense tension and whether its detection is important to satisfy the SAC remain controversial. We generated a HeLa cell line in which two components of the kinetochore, centrome...
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The two daughter cells that result from each and every cell division receive an identical set of chromosomes. This is accomplished by pulling each copy of a pair of duplicated sister chromatids to opposite poles during mitosis. Inaccuracies in this process lead to aneuploidy, which is a major cause of birth defects and can facilitate the rise of malignancies. Such inaccuracies are prevented in ...
متن کاملKinetochore-Microtubule Interactions
Kinetochores are the multiprotein macromolecular assemblies on chromatin that ensure the accurate and timely segregation of chromosomes at duringmitosis. To achieve this, kinetochores must interact with the microtubules of the spindle andmicrotubule-associated proteins. The nature of the kinetochore–microtubule interaction varies during the stages of the mitotic cycle, starting with initial cap...
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ژورنال
عنوان ژورنال: G3 Genes|Genomes|Genetics
سال: 2016
ISSN: 2160-1836
DOI: 10.1534/g3.116.031930